Continuous five-day infusion of pala and 5FU: A pilot phase II trial

✍ Scribed by Presant, Cary A. ;Ardalan, Bach ;Multhauf, Phyllis ;Chan, Clara ;Staples, Russell ;Green, Leland ;Browning, Scott ;Carr, Brian I. ;Chang, Fong-Fu ;Thayer, William

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 187 KB
• Volume: 11
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950110305

✦ Synopsis

In order to determine whether a simultaneous infusion of N-(phospho-n-acetyl)-L-aspartic acid (PALA) was able to increase the rate of antitumor response to 5-fluorouracil (5-FU), a pilot study was conducted. Of 10 evaluable patients with previously drug-untreated colorectal carcinoma, there were only two partial responses, lasting 2.3 and 1.6 months. No partial responses were observed in three evaluable patients with soft tissue sarcomas. The dose-limiting toxicity was dermatitis. The simultaneous infusion of PALA and 5-FU is not likely to produce a high number of antitumor responses of long duration in patients with colorectal carcinoma.