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Continuous dopaminergic stimulation: Is it the answer to the motor complications of Levodopa?

✍ Scribed by John G. Nutt

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
84 KB
Volume
22
Category
Article
ISSN
0885-3185

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✦ Synopsis

Continuous dopaminergic stimulation (CDS) is a treatment strategy hypothesized to avoid or reduce the motor complications of long-term levodopa therapy, motor fluctuations, and dyskinesia, by preventing or reversing sensitization induced by pulsatile dopaminergic stimulation. The CDS hypothesis is itself based on several hypotheses. First, tonic dopaminergic stimulation is physiological. Second, sensitization is undesirable and should be reversed. Third, reduction of off time and dyskinesia can be induced simultaneously. Finally, clinical studies substantiate the CDS hypothesis. The evidence for these hypotheses is reviewed, and the need for randomized clinical trials that rigorously test the CDS hypothesis is emphasized.

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