✍ Scribed by Randall M. Kroeker; Cindy A. Stewart; Michael J. Bronskill; R. Mark Henkelman
No coin nor oath required. For personal study only.
In vivo measurements of T I and T2 values in two experimental tumors growing in the legs of mice were made during tumor growth and after treatment of the tumor with either X-rays or cyclophosphamide. The T I and T2 values were obtained by fitting the data to continuous distributions of relaxation times. This technique gives broad distributions of relaxation times which are characterized by a number of peaks with characteristic T I and T, values. Before treatment, the T I and T2 values increased before a palpable tumor mass could be detected. The response to subcurative doses of either treatment method was a reduction in the TI and Tz values and a parallel reduction in tumor weight. Although local recurrence was characterized by the same pattern of tumor growth as was observed before treatment, therapy was found to give higher relaxation time values than those measured in untreated tumors. The higher relaxation time values of tumor-bearing legs were the result of redistribution of the peaks in the distribution and not changes in the relaxation times of the individual peaks. 0 1988 Academic PI=, inc.
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