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Continuous delivery of IFN-beta sensitizes human gliomas to ionizing radiation

โœ Scribed by John B. Hamner; Paxton Dickson; Mostafa W. Gaber; Cathy Ng; Junfang Zhou; Andrew Davidoff


Book ID
113677347
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
49 KB
Volume
203
Category
Article
ISSN
1072-7515

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Farnesyltransferase inhibitor, R115777,
โœ Caroline Delmas; Christophe Heliez; Elizabeth Cohen-Jonathan; Dave End; Jacques ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 425 KB

## Abstract We investigated for the first time the ability of farnesyltransferase inhibitors (FTI) to radiosensitize human glioma. For this, human glioma cell lines were treated with the specific FTI, R115777, 48 hr prior to a 2Gy irradiation. The treatment with R115777 decreased by 45% the SF2 val