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Continuous covariate imbalance and conditional power for clinical trial interim analyses

✍ Scribed by Ciolino, Jody D.; Martin, Renee' H.; Zhao, Wenle; Jauch, Edward C.; Hill, Michael D.; Palesch, Yuko Y.

Book ID
122148712
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
925 KB
Volume
38
Category
Article
ISSN
1551-7144

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CONTINUOUS AND GROUP SEQUENTIAL CONDITIO
CONTINUOUS AND GROUP SEQUENTIAL CONDITIONAL PROBABILITY RATIO TESTS FOR PHASE II CLINICAL TRIALS
✍ MING TAN; XIAOPING XIONG πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 1020 KB

We present continuous and group sequential designs for phase I1 clinical trials based on the sequential conditional probability ratio test (SCPRT). The SCPRT is derived from a conditional likelihood ratio, where the conditioning is on what the corresponding (reference) fixed sample size test (RFSST)