Continued mapping of chromosome 2 genes

✍ Scribed by Ralph J. Graff; Vera Hauptfeld; Kevin Riordan; Michael Kurtz

• Publisher: Springer-Verlag
• Year: 1994
• Tongue: English
• Weight: 881 KB
• Volume: 40
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00163960

✦ Synopsis

This report describes our continued efforts to elucidate the genetic fine structure of the central portion of the mouse chromosome (Chr) 2. Mice from our panel of 28 Chr 2 congenic strains were tested: 1) for the presence of the antigens which stimulate Chr 2-reactive lymphocyte clones in mixed lymphocyte reaction (MLR); 2) for the antigens of histocompatibility (H) genes H-42 a and H-45 a as determined by allograft rejection; and 3) for their ability to respond to the H-Y antigen in a cell-mediated lysis assay. The results obtained in this study have allowed additional mapping of immunologically involved Chr 2 genes. The gene encoding the antigen which stimulates lymphocyte clone 1Cll can be considered wholly different from other Chr 2 H genes on the basis of chromosomal recombination.