Contemporary Research on Renal Cell Carcinoma: Basic and Clinical Developments

✍ Scribed by E. A. Klein (auth.), Professor Dr. med. Gerd Staehler, PD Dr. med. Sigmund Pomer (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1994
• Tongue: English
• Leaves: 164
• Edition: 1
• Category: Library

✦ Synopsis

The management of advanced renal cell carcinoma is still problematic. Surgery, although the therapy of choice for locally advanced renal tumors, is still controversial as the treatment for metastases. The role of surgery in the management of patients with pulmonary, bony, and liver metastasis is one of the subject matters discussed in this book. Our results with series of patients undergoing resection of metastases from the lung, bone, and liver show that surgery may be appropriate in selected patients with a good performance status, although most of them certainly cannot be cured by this procedure alone, i.e., in the absence of effective adjuvant therapies. As recent developments show, new strategies for immunotherapy of renal cell carcinoma represent a modest advance over traditional approaches in the treatment of this cancer, such as chemo- and radiotherapy. Clinical trials employing recombinant interferon-a and interleukin 2 produced response rates in up to 30% of patients treated, as evidenced by the European Immunotherapy Trials Program. The adverse reactions and the lack of efficacy in the majority of patients warrants the search for new immunotherapeutic approaches.

✦ Table of Contents

Front Matter....Pages I-XII
Front Matter....Pages 1-1
The Role of Nephrectomy in Metastatic Renal Cell Carcinoma....Pages 3-9
Possibilities and Limitations of Surgery for Liver Metastases of Renal Cell Cancer....Pages 10-18
The Role of Bone Surgery for Immunotherapy in Disseminated Renal Cell Cancer....Pages 19-29
Survival After Lung Surgery for Metastatic Renal Cancer....Pages 30-38
Partial Nephrectomy for Renal Cell Carcinoma: Clinical and Biological Considerations....Pages 39-46
Investigation of the Tumor Capsule in Renal Cell Carcinoma and Its Significance for Treatment....Pages 47-55
Interleukin-2 Therapy: Report on 129 Patients and Three Different Schedules....Pages 56-62
Response According to Site of Metastases in Patients with Metastatic RCC (Renal Cell Carcinoma) During Treatment with Interferon Alpha in Combination with 5-Fluorouracil....Pages 63-65
Front Matter....Pages 67-67
Molecular Mapping of the Human 3p Region....Pages 69-79
Molecular Analysis of Different Loci on Chromosomes 3, 5, and 17 in Sporadic Renal Cell Carcinoma....Pages 80-89
Expression of Immediate Early Transcription Factors in Human Renal Cell Tumors....Pages 90-96
Characterization and Functional Significance of the von Hippel-Lindau Gene in Renal Cell Carcinomas....Pages 97-103
In Situ Expression of Cytokines in Renal Cell Carcinoma....Pages 104-111
Tumor-Infiltrating Lymphocytes in Renal Cell Carcinoma: Phenotype, Function, and T-Cell Receptor Usage....Pages 112-120
Immunological Approaches to Reverse Multidrug Resistance: The Concept of Molecular Targeting....Pages 121-131
Therapeutic Applications of Monoclonal Antibodies in Combination with Cytokines in Renal Cell Carcinoma....Pages 132-140
Tools for Vaccination and Immunotherapy: Internal-Image Anti-idiotype Antibodies Resembling the Renal Cell Carcinoma Associated Antigen G250....Pages 141-147
Laser Photodynamic Therapy of Xenotransplanted Human Renal Cell Carcinoma....Pages 148-155
Back Matter....Pages 157-158

✦ Subjects

Urology/Andrology; Oncology; Immunology