Contemporary liquid chromatography column design

✍ Scribed by R.P.W. Scott

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 1016 KB
• Volume: 468
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)96309-x

✦ Synopsis

The development of chromatographic column theory over the last thirty years is described and the impact of the plate theory and rate theory on column design discussed. The concept of the reduced chromatogram is employed to develop equations for optimum column length, optimum column diameter, optimum particle size and minimum analysis time. The equations are used to identify the practical limits of column design and column performance, and the design of a family of columns for general liquid chromatography analysis is recommended.