✦ LIBER ✦

Contemporary approaches to protein structure classification

✍ Scribed by Mark B. Swindells; Christine A. Orengo; David T. Jones; E. Gail Hutchinson; Janet M. Thornton

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 756 KB
Volume: 20
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(199811)20:11<884::aid-bies3>3.0.co;2-h

No coin nor oath required. For personal study only.

✦ Synopsis

In a similar manner to sequence database searching, it is also possible to compare three-dimensional protein structures. Such methods can be extremely useful because a structural similarity may represent a distant evolutionary relationship that is undetectable by sequence analysis. In this review, we summarise the most popular structure comparison methods, show how they can be used for database searching, and then describe some of the most advanced attempts to develop comprehensive protein structure classifications. With such data, it is possible to identify distant evolutionary relationships, provide libraries of unique folds for structure prediction, estimate the total number of folds that exist, and investigate the preference for certain types of structures over others.

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