Protease-mediated arsenic prodrug strate
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Emanuele Bellacchio; Marco G. Paggi
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Article
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2007
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John Wiley and Sons
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English
β 214 KB
## Abstract A strategy for the selective in vivo activation of prodrugs by proteases is presented. The approach is based on the design of polythiol peptides able to neutralize the toxicity of As(III) through chelation, and contemporarily to be recognized as substrates of a diseaseβlinked specific p