✦ LIBER ✦
Construction of the ingenane core using an Fe(III) or Ti(IV) Lewis acid-catalyzed intramolecular [6+4] cycloaddition
✍ Scribed by James H. Rigby; Mike Fleming
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 121 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A facile entry into the ingenane core using a Lewis acid-catalyzed intramolecular [6+4] cycloaddition has been developed. Ti(IV)-and Fe(III)-based Lewis acids were found to mediate the higher order cycloaddition in good to excellent yield at room temperature. Chiral Ti(IV) Lewis acids were found to induce modest asymmetry in the resultant [6+4] cycloadducts.