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Construction of Optically Active CF3-Containing Quaternary Carbon Centers via Stereospecific SN2′ Reaction.

✍ Scribed by Mitsuo Kimura; Takashi Yamazaki; Tomoya Kitazume; Toshio Kubota


Book ID
101971482
Publisher
John Wiley and Sons
Year
2005
Weight
48 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract The asymmetric construction of quaternary carbon centers __via__ cross‐aldol reactions of ketones with β,γ‐unsaturated keto esters catalyzed by 4‐(__tert__‐butyldiphenylsilyloxy)‐pyrrolidine‐2‐carboxylic acid in water is described. The adducts bearing two adjacent chiral centers were ob