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Construction of heteroduplex DNA andin vitromodel for functional analysis of mismatch repair

✍ Scribed by Yi Wang; Alan Clark; Jiaxun Wang; Menghong Sun; Daren Shi


Book ID
105648558
Publisher
Springer
Year
2004
Tongue
English
Weight
315 KB
Volume
49
Category
Article
ISSN
1001-6538

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## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The