Construction of heteroduplex DNA andin vitromodel for functional analysis of mismatch repair
β Scribed by Yi Wang; Alan Clark; Jiaxun Wang; Menghong Sun; Daren Shi
- Book ID
- 105648558
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 315 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1001-6538
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is caused by DNA variations in the DNA mismatch repair (MMR) genes MSH2, MLH1, MSH6, and PMS2. Many of the mutations identified result in premature termination of translation and thus in loss-of-function of the encoded mutated prote
The hereditary colon and endometrium cancer predisposition Lynch Syndrome (also called HNPCC) is caused by a germ-line mutation in one of the DNA mismatch repair (MMR) genes. A significant fraction of the gene alterations detected in suspected Lynch Syndrome patients is comprised of amino acid subst
Use of a DNA toolbox for the characterization of mutation scanning methods. I: Construction of the toolbox and evaluation of heteroduplex analysis A systematic characterization of the effects of important physical parameters on the sensitivity and specificity of methods in searching for unknown base
## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The