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Construction of CpG motif-enriched DNA vaccine plasmids for enhanced early immune response

✍ Scribed by Young Seoub Park; Seung Ha Hwang; Cha-Yong Choi

Publisher
The Korean Society for Biotechnology and Bioengineering
Year
2005
Tongue
English
Weight
267 KB
Volume
10
Category
Article
ISSN
1226-8372

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Enhancement of humoral immune responses
Enhancement of humoral immune responses to a human cytomegalovirus DNA vaccine: Adjuvant effects of aluminum phosphate and CpG oligodeoxynucleotides
✍ Nigel J. Temperton; Debra C. Quenelle; Keirissa M. Lawson; Jane N. Zuckerman; Ea πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 107 KB

## Abstract A human cytomegalovirus (HCMV) glycoprotein B (gpUL55) DNA vaccine has been evaluated in BALB/c mice. Intramuscular immunization of these mice with pRc/CMV2‐gB resulted in the generation of high levels of gpUL55‐specific antibody (geometric mean titer [GMT] 1:8900) and neutralizing anti