Construction of chiral quaternary carbon centers by asymmetric alkylation of achiral lithium enolates mediated by chiral tetradentate ligands: Stoichiometric and catalytic approaches

✍ Scribed by Yasuhiro Yamashita; Kazunori Odashima; Kenji Koga

• Book ID: 104261093
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 217 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00299-3

✦ Synopsis

Enantioselective asymmetric alkylation of achiral lithium enolates mediated by chiral tetradentate amine ligands is achieved to give chiral quaternary carbon centers. Turnover of a chiral tetradentate amine in the presence of an achiral bidentate amine during the reaction is also realized.