In colorectal cancer, matrilysin (matrix metalloproteinase-7) is mainly produced by the tumor cells themselves and is thought to play an important role in tumor invasion and metastasis. In the study reported here, we examined the effects of matrilysin antisense phosphorothioate oligonucleotides on b
β¦ LIBER β¦
Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells
β Scribed by Wu Mingfu; Shi Yanyan; Xi Lin; Li Qiong; Liao Guo-Nin; Han Zhi-Qiang; Lu Yuh-Ping; Ma Ding
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- Chinese
- Weight
- 361 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0510-9752
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## Abstract Ovarian cancer is a gynecological malignancy with high mortality. Therefore, the identification of novel prognostic and therapeutic targets is important. p21βactivated kinases (Paks) are involved in cytoskeleton reorganization. This study investigated the clinical significance of total