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Construction of a Part of a 3-Hydroxypropionate Cycle for Heterologous Polyketide Biosynthesis in Escherichia coli

โœ Scribed by Yuzawa, Satoshi; Chiba, Naoki; Katz, Leonard; Keasling, Jay D.


Book ID
120311080
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
372 KB
Volume
51
Category
Article
ISSN
0006-2960

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## Abstract 6โ€Deoxyerythronolide B (6dEB) is the macrocyclic aglycone precursor of the antibiotic natural product erythromycin. Heterologous production of 6dEB in __Escherichia coli__ was accomplished, in part, by designed overโ€expression of a native __prpE__ gene (encoding a propionylโ€CoA syntheta