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Construction of a combinatorial library of 2-(4-oxo-4H-1-benzopyran-3-yl)-4-thiazolidinones by microwave-assisted one-pot parallel syntheses

✍ Scribed by Zhong-Zheng Zhou; Wei Huang; Feng-Qin Ji; Ming-Wu Ding; Guang-Fu Yang

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 200 KB
Volume: 18
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20309

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✦ Synopsis

Abstract

A one‐pot liquid‐phase combinatorial synthesis of 2‐(4‐oxo‐4__H__‐1‐benzopyran‐3‐yl)‐4‐thiazolidinones bearing diverse substituents at the 3‐position under microwave irradiation was successfully performed using 3‐formyl chromone, primary amine, and mercaptoacetic acid as reactants. Compared to an identical library generated by conventional parallel synthesis, the microwave‐assisted parallel synthesis approach dramatically decreased the reaction time from an average of 9 h to 5 min, and substantially increased the product yields. The coupling of microwave technology with liquid‐phase combinatorial synthesis constitutes a novel and particularly attractive avenue for the rapid generation of structurally diverse libraries. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:381–389, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20309

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