✦ LIBER ✦
Construction of 1,2,5-Tricarbonyl Compounds using Methyl Cyanoacetate as a Glyoxylate Anion Synthon Combined with Copper(I) Iodide-Catalyzed Aerobic Oxidation
✍ Scribed by Se Hee Kim; Ko Hoon Kim; Jae Nyoung Kim
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 233 KB
- Volume
- 353
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
A practical and efficient synthesis of various 1,2,5‐tricarbonyl compounds is described. The synthesis has been carried out by a conjugate addition of methyl cyanoacetate to the β‐position of α,β‐unsaturated carbonyl compounds and a subsequent copper(I) iodide‐catalyzed aerobic oxidation. In addition, various α‐aryl‐ and α‐alkyl‐α‐keto esters have been synthesized using a similar approach.