Construction and synthesis of lactoferricin derivatives with enhanced antibacterial activity

✍ Scribed by Øystein Rekdal; Jill Andersen; Lars H. Vorland; John S. Svendsen

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 480 KB
• Volume: 5
• Category: Article
• ISSN: 1075-2617
• DOI: 10.1002/(sici)1099-1387(199901)5:1<32::aid-psc172>3.0.co;2-9

✦ Synopsis

A series of peptides derived from sequences from human, bovine, murine and caprine lactoferrin has been prepared and investigated for antibacterial effect. Among the four species investigated peptides based on the bovine sequence displayed significant activity. The bovine sequence, bovine lactoferricin, showed a MIC value of 30 mg/mL on E. coli and S. aureus, whereas the three other lactoferricins possessed MIC values above 200 mg/mL. Based on these findings, novel peptides with enhanced antibacterial activities, were prepared with sequences designed by molecular modelling and structure-activity studies.