Construction and performance of plug-in membrane inlet mass spectrometer for fermentor monitoring

✍ Scribed by Michael Schou; Thomas Graf; Hans Degn

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 235 KB
• Volume: 54
• Category: Article
• ISSN: 0006-3592
• DOI: 10.1002/(sici)1097-0290(19970620)54:6<535::aid-bit4>3.0.co;2-k

✦ Synopsis

An in situ sterilizable plug-in membrane inlet cation in fermentor monitoring was published in 1975 mass spectrometer for monitoring dissolved gases and (Reuss et al., 1975). Since then many papers on the volatiles in fermentors was constructed and tested. The use of MIMS for fermentor monitoring have appeared design ensured a minimal distance to be traveled by ana- (Degn, 1992; Heinzle, 1987). However, published evilyte molecules from the bulk of the fermentation broth dence on the practical use of the technique in industry to the ionization chamber of the mass spectrometer. Apart from the specific cross talk due to overlapping mass peaks is scarce. This may be due to a variety of problems from different compounds, we found that carbon dioxide such as insufficient long-term stability, cross talk, slow interfered unspecifically with all the mass peaks of other response to organic volatiles, and sensitivity to temperasubstances, changing them by the same factor. The interture and sample pressure (Chauvatcharin et al., 1995; ference changed slowly with time and could be positive