𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40

✍ Scribed by Jürgen Bajorath; Alejandro Aruffo

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
415 KB
Volume
27
Category
Article
ISSN
0887-3585

No coin nor oath required. For personal study only.

✦ Synopsis

The interaction between the human B cell receptor CD40 and its ligand on T cells is critical for B cell proliferation and the regulation of humoral immune responses. CD40 is a member of the tumor necrosis factor receptor (TNFR) family. We report here the construction and analysis of a detailed threedimensional model of the TNFR-homologous extracellular region of CD40. This study provides an example for structure-based model building in the presence of low sequence similarity. The assessment of model quality and sequence-structure compatibility is emphasized, and limitations of the model are discussed. The current CD40 model predicts structural details beyond the backbone level. Features of the CD40 ligand binding site are discussed in conjunction with the results of a previous mutagenesis study. Proteins 27:59-70

📜 SIMILAR VOLUMES

Three-dimensional model of the ligand bi
Three-dimensional model of the ligand binding domain of the nuclear receptor for 1α,25-dihydroxy-vitamin D3
✍ Anthony W. Norman; Derk Adams; Elaine D. Collins; William H. Okamura; Robert J. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 449 KB

A three-dimensional model for residues 142-427 of the ligand binding domain (LBD) of the human nuclear receptor for 1␣,25-dihydroxy-vitamin D 3 [VDR] has been generated based on the X-ray crystallographic atomic coordinates of the LBD of the rat ␣1 thyroid receptor (TR). The VDR LBD model is an elon

Structural analysis of the thyroid hormo
Structural analysis of the thyroid hormone receptor ligand binding domain: studies using a quadrupole time-of-flight tandem mass spectrometer
✍ Andreas P. Jonsson; Mats Carlquist; Bolette Husman; Jan Ljunggren; Hans Jörnvall 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 2 views

The overall architecture of the ligand binding domain (LBD) of members of the nuclear receptor superfamily are similar. There are now standard procedures to express and purify these proteins. A rapid and sensitive method for the structural analysis of these proteins is nano-electrospray tandem mass

Evaluation of synergism by a novel three
Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line, SBC-3
✍ Fumihiko Kanzawa; Kazuto Nishio; Kazuya Fukuoka; Minoru Fukuda; Takehiko Kunimot 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 206 KB 👁 1 views

Although the combination of cisplatin and etoposide has been used as standard therapy for small-cell lung cancer, it is difficult to demonstrate combination effects between cisplatin and etoposide in vitro. We therefore adopted a 3-dimensional (3-D) model to analyze the combination effects of antica