Constructing Circuits: Neurogenesis and Migration in the Developing Neocortex
โ Scribed by Arnold R. Kriegstein
- Book ID
- 109108520
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2005
- Tongue
- English
- Weight
- 292 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0013-9580
No coin nor oath required. For personal study only.
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## Abstract The cell kinetics of the developing central nervous system (CNS) is determined by both proliferation and apoptosis. In the human neocortex at week 6 of gestation, proliferation is confined to the ventricular zone, where mitotic figures and nuclear immunoreactivity for proliferating cell
In mammalian species studied to date, the first-born neocortical cells normally form two layers, one above and one below the cortical plate, called the marginal zone (future layer 1) and the subplate. In primates and carnivores, many of these first-born cells die early in postnatal life. Whether thi