Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors
โ Scribed by Asmaa B. Hamze; Shuo Wei; Harinath Bahudhanapati; Smitha Kota; K. Ravi Acharya; Keith Brew
- Book ID
- 111753030
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 2007
- Tongue
- English
- Weight
- 281 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0961-8368
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## Abstract According to recent investigations, the __C__โterminal domain of the tissue inhibitor of matrix metalloproteinasesโ1 (TIMPโ1) is responsible for some biological effects that are independent of the enzymeโinhibiting effect of the __N__โterminal domain of the molecule. The __C__โterminal
We analyzed blood plasma concentrations of matrix metalloproteinase-1 and -3 (MMP-1; MMP-3), the tissue inhibitor of metalloproteinase-1 (TIMP-1) and the complex MMP-1/ TIMP-1, and looked for any correlation with prostate cancer stage. These components were measured by ELISA tests specific for these