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Constitutively active RhoA inhibits proliferation by retarding G1 to S phase cell cycle progression and impairing cytokinesis

✍ Scribed by Pierre Morin; Cristina Flors; Michael F. Olson

Book ID: 113582765
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 805 KB
Volume: 88
Category: Article
ISSN: 0171-9335
DOI: 10.1016/j.ejcb.2009.04.005

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## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia