Constitutive overexpression of c-fos protein in rat liver epithelial cells decreases TGF-β synthesis and increases TGF-β1 receptors
✍ Scribed by Thierry Mercier; Isabelle Gaillard-Sanchez; Paule Martel; Christine Seillan-Heberden
- Book ID
- 116106110
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 919 KB
- Volume
- 1266
- Category
- Article
- ISSN
- 0167-4889
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Transforming growth factor-beta1 (TGF-beta1) is widely recognized for its multiple roles in development, cellular maintenance, and protection against injury. In the brain, TGF-beta1 upregulation in microglia/macrophages is a predominant response to lesion and during pathology. However, the precise f
In the rat liver epithelial cell line, WB, the ability of TGF-P, to inhibit DNA synthesis was shown to correlate with its ability to inhibit phosphorylation of the protein product of the retinoblastoma susceptibility gene, pRb. When WB cells were serum-starved, then refed with serum-containing mediu
We examined the effect of the stable transfection of latent TGF-1 cDNA, under the control of a cytomegalovirus promoter in the expression vector pcDNA3, into a 4NQOinduced clonal rat oral keratinocyte cell line that formed undifferentiated spindle cell tumours following subcutaneous transplantation