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Constitutive Nuclear Factor-κB Activity Is Crucial for Human Retinoblastoma Cell Viability

✍ Scribed by Vassiliki Poulaki; Constantine S. Mitsiades; Antonia M. Joussen; Alexandra Lappas; Bernd Kirchhof; Nicholas Mitsiades


Book ID
117022246
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
513 KB
Volume
161
Category
Article
ISSN
0002-9440

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## Abstract Hodgkin/Reed‐Sternberg (H/RS) cells are believed to represent clonal progeny of Germinal Centre B cells that have escaped negative selection by evading apoptosis. Aberrant constitutive activity of the transcription factor NF‐κB plays a key role in the pathogenesis of Hodgkin's Lymphoma