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Constitutive membrane association potentiates activation of Bruton tyrosine kinase

✍ Scribed by Li, Tianjian; Rawlings, David J; Park, Hyunsun; Kato, Roberta M; Witte, Owen N; Satterthwaite, Anne B


Book ID
110060901
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
529 KB
Volume
15
Category
Article
ISSN
0950-9232

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Bruton's tyrosine kinase (Btk) is a member of the Tec family of protein tyrosine kinases (PTK) characterized by an N-terminal pleckstrin homology domain (PH) thought to directly interact with phosphoinositides. We report here that wild-type (wt) and also a gain-of-function mutant of Btk are redistri