Constitutive membrane association potentiates activation of Bruton tyrosine kinase
β Scribed by Li, Tianjian; Rawlings, David J; Park, Hyunsun; Kato, Roberta M; Witte, Owen N; Satterthwaite, Anne B
- Book ID
- 110060901
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 529 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Bruton's tyrosine kinase (Btk) plays a crucial role in the maturation and differentiation of Bβlymphocytes and immunoglobulin synthesis. Recently Btk has been described to be present in significant amount in human platelets. To investigate the regulation of this kinase in the platelets
Bruton's tyrosine kinase (Btk) is a member of the Tec family of protein tyrosine kinases (PTK) characterized by an N-terminal pleckstrin homology domain (PH) thought to directly interact with phosphoinositides. We report here that wild-type (wt) and also a gain-of-function mutant of Btk are redistri