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Constitutive heterochromatin of chromosome 1 and Duffy blood group alleles in schizophrenia

✍ Scribed by Kosower, N. S. ;Gerad, L. ;Goldstein, M. ;Parasol, N. ;Zipser, Y. ;Ragolsky, M. ;Rozencwaig, S. ;Elkabetz, E. ;Abramovitch, Y. ;Lerer, B. ;Weizman, A.

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 589 KB
Volume: 60
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320600209

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✦ Synopsis

Cytogenetic analysis was carried out in unrelated schizophrenic patients, unrelated controls and patients and family members in multiplex families. The size distribution of chromosome 1 heterochromatic region (lqH, C-band variants) among 21 unrelated schizophrenic patients was different from that found in a group of 46 controls. The patient group had 1qH variants of smaller size than the control group (P < 0.01). Incubation of phytohemagglutinin-treated blood lymphocytes with 5-azacytidine (which causes decondensation and extension of the heterochromatin) led to a lesser degree of heterochromatin decondensation in a group of patients than in the controls (7 schizophrenic, 9 controls, P < 0.01). The distribution of phenotypes of Duffy blood group system [whose locus is linked to the 1qH region (Donahue et al.:

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