Despite the reported absence of the 25-kDa heat shock protein Hsp25 in the rodent cerebellum, we have determined that Hsp25 is constitutively expressed in a subset of Purkinje cells in the adult cerebellum of the mouse. No other cerebellar neurons are Hsp25 immunoreactive, but there is weak staining
Constitutive expression of heat shock protein HSP25 in the central nervous system of the developing and adult mouse
β Scribed by Carol L. Armstrong; Anne Marie Krueger-Naug; R. William Currie; Richard Hawkes
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 670 KB
- Volume
- 434
- Category
- Article
- ISSN
- 0021-9967
- DOI
- 10.1002/cne.1176
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We employed whole-mount in situ hybridization and immunohistochemistry to study the spatial pattern of hsp30 gene expression in normal and heatshocked embryos during Xenopus laevis development. Our findings revealed that hsp30 mRNA accumulation was present constitutively only in the cement gland of
Growth factor and cytokine signalling in the developing nervous system has multiple effects, ranging from cell differentiation and cell survival to modulation of cell phenotype. Molecules that can regulate growth factor signalling pathways will therefore be of importance in determining the cellular
The 25-kDa heat-shock protein (Hsp25) is a member of the small heat-shock protein family but its function remains largely unknown. In the present study we examined the expression and cellular localization of Hsp25 mRNA in mice under physiological, unstressed conditions using Northern blot and in sit