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Constitutive Activity and Inverse Agonists of G Protein-Coupled Receptors: a Current Perspective

✍ Scribed by Milligan, G.


Book ID
118069163
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2003
Tongue
English
Weight
186 KB
Volume
64
Category
Article
ISSN
0026-895X

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## Abstract It has been recently established that G‐protein‐coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so‐called inverse agonists. For a number of GPCRs, such inverse agonists have been developed a