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Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain

✍ Scribed by Laurence Duprez; Jasmine Parma; Sabine Costagliola; Jacques Hermans; Jacqueline Van Sande; Jacques E Dumont; Gilbert Vassart


Book ID
117107663
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
817 KB
Volume
409
Category
Article
ISSN
0014-5793

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The N-terminal domain of GPR61, an orpha
✍ Masaru Toyooka; Takashi Tujii; Shigeki Takeda πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 191 KB

## Abstract G‐protein‐coupled receptor 61 (GPR61) is an orphan receptor that is abundantly expressed in the brain, which suggests its involvement in various physiological functions in the central nervous system. It couples with Gs and shows constitutive activity. To investigate the role of the N‐te