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Constitutive activation of c-Abl/protein kinase C-δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma

✍ Scribed by S. Noda; Y. Asano; K. Akamata; N. Aozasa; T. Taniguchi; T. Takahashi; Y. Ichimura; T. Toyama; H. Sumida; K. Yanaba; Y. Tada; M. Sugaya; T. Kadono; S. Sato

Book ID
117945744
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
413 KB
Volume
167
Category
Article
ISSN
0007-0963

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## Abstract Hyaluronan accumulation in the retroorbital connective tissue is one of the pathological features of Graves' ophthalmopathy. Interleukin‐1β (IL‐1β) is known to stimulate hyaluronan synthesis in orbital fibroblasts. In the present study, the intracellular signal transduction pathways inv