Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis

Targeting constitutive and interleukin-6

Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)

✍ Nitin Chakravarti; Jeffrey N. Myers; Bharat B. Aggarwal 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 782 KB

## Abstract Numerous reports suggest that interleukin‐6 (IL‐6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell‐signaling protein, signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carc