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Constitutional t(15;17): Clarification of the chromosomal breakpoints

✍ Scribed by Michelle M. Le Beau; Janet D. Rowley; María Teresa Ferro; Carlos San Román

Book ID
119103247
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
181 KB
Volume
20
Category
Article
ISSN
0165-4608

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A reciprocal chromosomal translocation, t( I 5; I7)(q22;q I I .2-I2), is characteristic of acute promyelocytic leukemia (APL) of French-American-British (FAB) subtype M3, and is not associated with any other human malignancy. The non-random pattern of the APL translocations suggests that specific ge