Constituents of holothuroidea, II. Six newly identified biologically active triterpenoid glycoside sulfates from the sea cucumberCucumaria echinata
✍ Scribed by Miyamoto, Tomofumi ;Togawa, Kenichi ;Higuchi, Ryuichi ;Komori, Tetsuya ;Sasaki, Takuma
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 824 KB
- Volume
- 1990
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
From the whole body of sea cucumber Cucumaria echinata (Cucumariidae), we recently identified six genuine holostane‐type triterpenoid glycoside sulfates designated as cucumechinoside A (1), B (2), C (3), D (4), E (5), and F (6). The structures 1–6 were determined on the basis of chemical and spectral investigations. Antitumor activities of these cucumechinosides and their solvolized compounds (10, 11, and 12) against murine lymphoma L 1210 and human epidermoid carcinoma KB cell in vitro were examined, and their antifungal and antiprotozoal activities were also investigated.