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Constant and steady transgene expression of interferon-γ by optimization of plasmid construct for safe and effective interferon-γ gene therapy

✍ Scribed by Mitsuru Ando; Yuki Takahashi; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura

Book ID
112121065
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
209 KB
Volume
14
Category
Article
ISSN
1099-498X

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## Abstract The lack of efficient T‐cell infiltration of tumors is a major obstacle to successful adoptive T‐cell therapy. We have previously demonstrated that adenovirus (AdV)‐mediated transgene lymphotactin (Lptn) or IP‐10 expression in tumors can significantly enhance T‐cell tumor infiltration.