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Conspiracy to disarm APC in interphase

โœ Scribed by Vodermaier, Hartmut C.; Peters, Jan-Michael


Book ID
109911565
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
90 KB
Volume
4
Category
Article
ISSN
1465-7392

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APC mutations introduce premature stop codons into the open reading frame of the gene, leading to the formation of truncated tumor suppressor proteins. Both RNA and protein levels are likely to be profoundly altered by such nonsense mutations. To test this hypothesis, Western blotting and RT-PCR str