Conspicuity of zones of ablation after radiofrequency ablation in porcine livers: Comparison of an extracellular and an SPIO contrast agent
✍ Scribed by Christopher Bangard; Dirk L. Stippel; Frank Berg; Hans U. Kasper; Martin Hellmich; Jürgen H. Fischer; Arnulf Hölscher; Klaus Lackner; Axel Gossmann
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 378 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To compare conspicuity of zones of ablation on nonenhanced, gadopentetate dimeglumine‐(Gd‐DTPA) and ferucarbotran‐(SPIO)‐enhanced magnetic resonance (MR) images.
Materials and Methods
In all, 33 radiofrequency ablations (RFA) were performed in 17 healthy porcine livers at 1.5T MR imaging 1 day and 2 and 4 weeks after RFA: T2‐weighted (w) ultra turbo spin echo (UTSE), proton density (PD)‐w UTSE, T1‐w gradient echo (GRE) pre‐ and 5 minutes postcontrast administration, dynamic T1‐w GRE during Gd‐DTPA (Magnevist) or SPIO (Resovist) administration, T2‐w UTSE, and PD‐w UTSE sequences 10 minutes after SPIO administration. Regions of interest (ROIs) for contrast‐to‐noise ratio (CNR) and signal‐to‐noise ratio (SNR) were drawn in consensus by two radiologists.
Results
PD‐w SPIO‐enhanced images (23.5 ± 5.5) showed higher liver‐to‐lesion CNR than T1‐w GRE Gd‐DTPA‐enhanced images (13.5 ± 6.1) 1 day after RFA (P ≤ 0.05). At all other timepoints, liver‐to‐lesion CNR of PD‐w and T2‐w SPIO‐enhanced images did not differ significantly from T1‐w GRE Gd‐DTPA‐enhanced images (P ≥ 0.05). Nonenhanced T2‐w images revealed lower liver‐to‐lesion CNR (7.0 ± 7.5/6.5 ± 5.9/6.8 ± 5.0, 1 day/2 weeks/4 weeks, respectively) than T2‐w SPIO‐enhanced (17.4 ± 4.8/15.3 ± 4.5/14.2 ± 5.7), PD‐w SPIO‐enhanced (23.5 ± 5.5/16.9 ± 3.6, 1 day/2 weeks), and T1‐w Gd‐DTPA‐enhanced (15.3 ± 3.6/12.7 ± 3.5, 2/4 weeks) images (P ≤ 0.05). Liver‐to‐lesion CNR of SPIO‐enhanced dynamic T1‐w GRE images after 30, 80, 150, and 240 seconds did not change significantly over time (P ≥ 0.05).
Conclusion
One day after RFA lesion conspicuity on PD‐w ferucarbotran‐enhanced images is better than on T1‐w GRE Gd‐DTPA‐enhanced images. At all other timepoints, ferucarbotran is not superior to gadolinium. Ferucarbotran‐ and gadolinium‐enhanced images improve lesion conspicuity compared with nonenhanced T2‐w images at all timepoints. J. Magn. Reson. Imaging 2008;28:263–270. © 2008 Wiley‐Liss, Inc.