Consistent occurrence of a 19p+ marker chromosome and loss of 11p material in ovarian seropapillary cystadenocarcinomas
✍ Scribed by Dr. Tanja Pejovic; Sverre Heim; Nils Mandahl; Bengt Elmfors; Ulla-Maria Flodérus; Stefan Furgyik; Göran Helm; Helena Willén; Felix Mitelman
- Book ID
- 102220751
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 477 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
Cytogenetic analysis of short-term cultures from I I moderately to poorly differentiated ovarian seropapillary cystadenocarcinomas revealed clonal chromosomal abnormalities in nine tumors. Two bands were involved in structural rearrangements in more than half of the tumors. The band most frequently affected was I9p I 3; rearrangements giving rise to a I9p+ marker chromosome were found in seven tumors, and in four of them the 19p+ markers appeared to be identical. Structural rearrangements resulting in loss of I I p 13-I I pter material were found in six tumors.
📜 SIMILAR VOLUMES
## Abstract Unstable, gene‐rich pericentric regions have been associated with various structural aberrations including small supernumerary marker chromosomes (sSMCs). We hereby report on a complex pure mosaic sSMCs derived from chromosomes 11 and 19 in a child featuring multiple congenital anomalie