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Consistent Bioactive Conformation of the Neu5Acα(2→3)Gal Epitope Upon Lectin Binding

✍ Scribed by Anirban Bhunia; Oliver Schwardt; Heiko Gäthje; Gan-Pan Gao; Soerge Kelm; Andrew J. Benie; Milos Hricovini; Thomas Peters; Beat Ernst


Book ID
101818748
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
466 KB
Volume
9
Category
Article
ISSN
1439-4227

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The first synthesis of neu5Acα2-3Galβ1-4
✍ Ichiro Matsuo; Megumi Isomura; Katsumi Ajisaka 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 212 KB

Glycopepfide (I), Neu5A~2-3Gall~l-4GlcNA~l-2Maactl-Ser, was synthesized using a chemoenzymatic strategy. Gal~l-4GlcNAcl~l\*2Man Ifisacd~ide was ~ using glycosidase assisted oligom:x:lutride synthesis. After coupling of this trisacchaxide with a sefine defivstive by chemical glycosylstion, sialic add