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Considering the cancer consequences of altered DNA polymerase function

✍ Scribed by Thomas A Kunkel

Book ID
114413274
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
168 KB
Volume
3
Category
Article
ISSN
1535-6108

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DNA polymerase Ξ² is essential for short-patch base excision repair. We have previously identified 20 somatic pol Ξ² mutations in prostate tumors, many of them missense. In the current article we describe the effect of all of these somatic missense pol Ξ² mutations (p.K27N, p.E123K, p.E232K, p.P242R, p