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Considerations When Analyzing the Methylation Status of PTEN Tumor Suppressor Gene

✍ Scribed by Michele A. Zysman; William B. Chapman; Bharati Bapat

Book ID
117022443
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
390 KB
Volume
160
Category
Article
ISSN
0002-9440

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## Abstract Germline mutations in the tumor‐suppressor gene __PTEN__ (__MMAC1, TEP1__) are found in Cowden syndrome, which predisposes to hamartomas, breast cancer, trichilemmomas, and thyroid tumors of follicular epithelium. __PTEN__ has also been found to be somatically deleted, mutated, and/or s

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The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found i