## Abstract Currently used antiestrogenic drugs against hormoneโdependent breast cancer, and estrogenic drugs used in treatment of osteoporosis, are associated with risk factors. Therefore, there is a strong need to develop selective estrogen receptor modulators with better tissue selectivity. In a
Considerations in the design and evaluation of cytotoxic estrogens
โ Scribed by John A. Katzenellenbogen; Benita S. Katzenellenbogen
- Publisher
- Springer US
- Year
- 1982
- Tongue
- English
- Weight
- 662 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract With the aim of enlightening some structureโactivity correlation within the pyranoxanthenone series, we have designed and synthesized a number of new 5โaminosubstituted pyrano[3,2โ__b__]xanthenโ6โones bearing various 12โsubstituents. __In vitro__ cytotoxic potencies of the new derivativ
## Abstract Five novel compounds composed of etoposide and 5โfluorouracil derivatives joined by an ester linkage were prepared and evaluated for their antitumor potential. Most of these analogues have exhibited promising __in vitro__ cytotoxic activity against cell cultures of murine leukaemia Pโ38