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Consideration of short-term carcinogenicity tests using transgenic mouse models

✍ Scribed by Peter G. Blain; Jon M. Battershill; Stanley Venitt; Colin C. Cooper; Robin J. Fielder

Book ID
114072264
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
58 KB
Volume
403
Category
Article
ISSN
0027-5107

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The transgenic mouse rasH2 line, in which the mouse carries the human c-Ha-ras gene under the control of its own enhancer and promoter, has been proposed as one of the alternative short-term models for carcinogenicity testing. To apply this purpose, we have produced a genetically homogeneous populat