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Conserved cytostatic activity of aclarubicin in a doxorubicin selected friend leukaemia cell line with multifactorial multidrug resistance

✍ Scribed by Rudolf Erttmann; Marianne Münchmeyer; Guido Looft; Kurt Winkler

Book ID
119157006
Publisher
Elsevier Science
Year
1991
Weight
159 KB
Volume
27
Category
Article
ISSN
0277-5379

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## Abstract A doxorubicin‐resistant variant of the human small‐cell lung‐cancer cell line N592 was selected by __in vitro__ continuous exposure to increasing drug concentrations. The aim of this study was to examine the cross‐resistance pattern, cellular pharmacokinetics of doxorubicin and expressi