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Conservation of the RBI gene in human and primates

✍ Scribed by Theru A. Sivakumaran; Peidong Shen; Dennis P. Wall; Bao H. Do; Kiran Kucheria; Peter J. Oefner

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
55 KB
Volume
25
Category
Article
ISSN
1059-7794

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✦ Synopsis

The original article to which this Erratum refers was published in Human Mutation 25: 396-409 (2005). In the last sentence of the paragraph on DHPLC under Materials and Methods (page 398, lines 10-11), it was stated erroneously that exon 8 of the RB1 gene is not translated. Exon 8 is translated. However, it was not subjected to DHPLC analysis unlike the other exons, but sequenced directly, because in silico analysis of the melting behavior of the amplified exon 8 and its flanking intronic sequences had shown part of the coding region to lie in a high-melting domain surrounded by low-melting domains. This raised concern that mutations in the high-melting domain might be missed by DHPLC analysis. Therefore, exon 8 was sequenced directly as indicated in the supplementary Table S1.

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