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Conservation of sequence and function in the Pax6 regulatory elements

✍ Scribed by Richard Morgan

Book ID
113932517
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
121 KB
Volume
20
Category
Article
ISSN
0168-9525

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We have identified a 338 bp DNA fragment, the lateral plate mesoderm (LPM) enhancer, that is highly conserved between mouse and human. The LPM enhancer directs gene expression into the posterior lateral plate mesoderm and hindgut endoderm at early stages of development. By reporter gene analysis in