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Consequences of NPC1 and NPC2 loss of function in mammalian neurons

✍ Scribed by Steven U. Walkley; Kinuko Suzuki

Book ID: 116272842
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 682 KB
Volume: 1685
Category: Article
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2004.08.011

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## Abstract The Niemann‐Pick C1 and C2 (NPC1 and NPC2) proteins have a central role in regulating the transport of lipoprotein‐derived cholesterol from endocytic compartments to the endoplasmic reticulum for esterification by acyl‐CoA:cholesterol acyltransferase (ACAT) and feedback inhibition of th