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Consequences of increased vascular permeability induced by treatment of mice with 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and thalidomide

✍ Scribed by Francisco Chung; Jenny Liu; Lai-Ming Ching; Bruce C. Baguley


Publisher
Springer
Year
2007
Tongue
English
Weight
316 KB
Volume
61
Category
Article
ISSN
0344-5704

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## Abstract The novel vascular targeting agent 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA) has completed phase 1 clinical trial and has shown tumor antivascular activity in both mice and humans. We have investigated its ability to change tumor vascular permeability, relating it to tumor vascular p