Mechanisms of tumor vascular shutdown in
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Liangli Zhao; Lai-Ming Ching; Philip Kestell; Lloyd R. Kelland; Bruce C. Baguley
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Article
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2005
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John Wiley and Sons
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French
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## Abstract The novel vascular targeting agent 5,6βdimethylxanthenoneβ4βacetic acid (DMXAA) has completed phase 1 clinical trial and has shown tumor antivascular activity in both mice and humans. We have investigated its ability to change tumor vascular permeability, relating it to tumor vascular p